In Soderbergh-world, the big city is full of dangerous lesbian killers that prey on soft decent men like Jude Law: Law restores law and re-balances Sodebergh-world by making sure nasty lesbians end up in jail or the insane asylum where they belong, just like in movies from 1945. Side-effects is a handsome, expert film; it’s got interesting things to say about drugs and pharmaceutical companies; but the most entertaining element in it is also what makes its representational politics so very nasty. Law is no longer pretty but who cares about pretty when he can play human and swayed and slightly weak but pushed to fight back and sometimes all of these things simultaneously and transparently? He is superb. Rooney Mara and Catherine Zeta-Jones seem to relish playing, respectively, women who are not quite in the distress they first appear to be; and women who are not quite in as much control as they initially seem: both are terrific. Channing Tatum is likeable but out of his league; the film itself is occasionally superb but generally unlikeable.